Preheat grill for medium heat and lightly oil the grate.
Combine ground beef, salt, black pepper, Greek yogurt and Hot Spread Sauce in a bowl; mix until well combined. Press into 4 equal hamburger patties
Grill patties until no longer pink in the center, 6 to 8 minutes per side. An instant-read thermometer inserted into the center should read at least 160 degrees F (70 degrees C). Top each with 1 slice provolone cheese; remove from grill.
Place 2 patties on each bun; top with 1 tomato slice, 1 onion slice, and 1 lettuce leaf.